Nevanac

Guide your patients through post-cataract recovery with
NEVANAC® suspension. It offers proven performance, safety, and
tolerability.^2-4 Plus the efficacy you demand:

Excellent control of inflammation³

Significantly more patients with resolved anterior segment inflammation vs placebo as early as Day 1²
Unique prodrug design leads to powerful COX-2 inhibition¹
Significantly more pain-free patients vs placebo as soon as Day 1²

INDICATIONS AND USAGE:

NEVANAC^® ophthalmic suspension is a nonsteroidal, anti-inflammatory prodrug indicated for the treatment of pain and inflammation associated with cataract surgery.

DOSAGE AND ADMINISTRATION:

Shake well before use. One drop of NEVANAC^® ophthalmic suspension should be applied to the affected eye(s) three-times-daily beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period.

NEVANAC^® ophthalmic suspension may be administered in conjunction with other topical ophthalmic medications such as beta-blockers, carbonic anhydrase inhibitors, alpha-agonists, cycloplegics, and mydriatics.

IMPORTANT SAFETY INFORMATION:

CONTRAINDICATIONS

Hypersensitivity to any of the ingredients in the formula or other NSAIDS.

WARNINGS AND PRECAUTIONS

Increased bleeding time due to increased thrombocyte aggregation
Delayed healing
Corneal effects including keratitis

ADVERSE REACTIONS

Most common adverse reactions (5% to 10%) are capsular opacity, decreased visual acuity, foreign body sensation, increased intraocular pressure, and sticky sensation.

References:
1. Walters T, Raizman M, Ernest P, Gayton J, Lehmann R. In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J Cataract Refract Surg. 2007;33(9):1539-1545. 2. Maxwell WA, Reiser HJ, Stewart RH, et al. Nepafenac dosing frequency for ocular pain and inflammation associated with cataract surgery. J Ocul Pharmacol Ther. 2008;24(6):593-599. 3. Lane SS, Modi SS, Lehmann RP, Holland EJ. Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. J Cataract Refract Surg. 2007;33(1):53-58. 4. NEVANAC^® suspension package insert.

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Steroids

Nonsteroidal anti-inflammatory drugs (NSAIDS)

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Aqueous humor drug concentration (0-4 h)